Additional references for data included in Tables 3 The references for each subfamily are numbered inside the supplementary Tables S2a S2f, and listed a icon

Additional references for data included in Tables 3 The references for each subfamily are numbered inside the supplementary Tables S2a S2f, and listed a

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1Supplementary materials

Additional references for data included in Tables 3 - 8. The references for each subfamily are numbered inside the supplementary Tables S2a - S2f, and listed at the end of the Table S2f.

Table S2a. Main subfamilies that conform PDH family (COG1063) of MDR.


DHSO (sorbitol dehydrogenase)

Ref: [155-157]

BDH (2,3-butanediol dehydrogenase)

Ref: [158-160]

^ TDH (threonine dehydrogenase)

Ref: [161-164]

BCHC (2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase)

Ref: [165;166]

^ SORE (L-sorbose-1-phosphate reductase)

Ref: [167-171]

Secondary ADH

Ref: [172-177]

^ GATD (galactitol 1-phosphate dehydrogenase)

Ref: [178-180]

SSP and related (sensing starvation protein)

Ref: [181;182]

^ FDEH (5-exo-hydroxycamphor dehydrogenase)

Ref: [183;184]

BDOR (bi-domain oxidoreductase)

Ref: [185]

^ Archaea GDH (glucose dehydrogenase)


FADH (formaldehyde dehydrogenase-independent of cofactor-/formaldehyde dismutase)

Ref: [190-196]

References are listed at the end of suplementary material.

Table S2b. Main subfamilies that conform ADH family (COG1062) of MDR.


^ Aryl/Alkyl ADH: Firmicutes

Ref: [197;198]

Benzyl ADH

Ref: Acinetobacter calcoaceticus [199-201]; Acinetobacter sp. [202;203]; Pseudomonas putida [204-206]; Pseudomonas sp.[207;208]; Sphingomonas aromaticivorans [209]; Rhizobium tropici [210]

HNL (Hydroxynitrile lyase: acetone cyanohydrin lyase)

Ref: [211-214]

^ FADH: mycothiol-dependent (formaldehyde dehydrogenase dependent of mycothiol)

Ref: [215-217]

Class III ADH (formaldehyde dehydrogenase dependent of glutathion)

Ref: [218-238]

^ Animal ADH

Ref: Homo sapiens: ADHA_HUMAN [239-242], ADHB_HUMAN [239;243-254], ADHG_HUMAN [239;255;256], ADHP_HUMAN [257;258], ADH6_HUMAN [259], ADH7_HUMAN [260-267]; Papio hamadryas [268-273]; Macaca mulatta [274;275], Equus caballus: ADHE_HORSE [276-280], ADHS_HORSE [277-280]; Oryctolagus cuniculus [281-284]; Mus musculus: ADH7_MOUSE [285;286], ADHA_MOUSE [285;287-290]; Peromyscus maniculatus [291]; Rattus norvegicus: ADHA_RAT [292;293]; ADH7_RAT [294]; ADH2t_RAT_CAA62241 [295]; Geomys [296;297]; Gallus gallus [298;299]; Coturnix coturnix japonica [300;301]; Anas platyrhynchos [302]; Apterix australis [303]; Struthio camelus [304;305]; Alligator mississippiensis [306]; Uromastix hardwickii [307;308]; Naja naja [309]; Rana perezi [310-312]; Xenopus laevis [313]; Gadus callarias [314;315]

Plant ADH

Ref: ^ Pinus banksiana [316]; Washingtonia robusta [317]; Calamus usitatus and Phoenix reclinata [318]; grasses (Poaceae)[319], Zea mays [320-322], Zea luxurians and Zea diploperennis [323], Sorghum bicolor [324]; Tripsacum dactyloides [325], Oryza sativa [326;327]; Pennisetum americanum [328]; Pennisetum glaucum [329]; Dioscorea tokoro and Dioscorea tenuipes [330]; Rhynchoryza subulata and Leersia perrieri [331]; Hordeum vulgare [332]; Vitis vinifera [333;334]; Paeonia [335;336]; Solanum tuberosum [337;338]; Pisum sativum [339]; Lactuca sativa [340]; Lycopersicon esculentum [341-344]; Petunia hybrida [345;346]; Phaseolus acutifolius [347]; Nicotiana tabacum [348]; Pyrus communis [349]; Arabis gemmifera and Arabidopsis thaliana [350;351]; Gossypium [352-355]

References are listed at the end of suplementary material.

Table S2c. Main subfamilies that conform CADH family and Y-ADH family (COG1064) of MDR.


^ CADH and related (cinnamyl alcohol dehydrogenase)

Ref: [356-370]

ELI3 (elicitor-inducible defense-related proteins)

Ref: [356;359;371-378]

^ Yeast ADH and related

Ref: Kluyveromyces lactis [379-382]; Emericella nidulans [383-385]; Candida albicans [386]; Schizosaccharomyces pombe [387]; Saccharomyces cerevisiae [388-392]; Bacillus stearothermophilus [393-395]; Zymomonas mobilis [396;397]; Sinorhizobium meliloti [398]; Brucella abortus [399]

Fungi MTD (mannitol-1-phosphate dehydrogenase)

Ref: [400-403]

^ Fungi secondary ADH

Ref: [404-406]

Broad ADH (broad substrate specificity ADH)

Ref: [407-415]

References are listed at the end of suplementary material.

Table S2d. Main subfamilies that conform QOR family and NRBP family (COG0504) of MDR.


-crystallin/QOR (quinone oxidoreductase)

Ref: [416-427]

^ PIG3 and related (animal P53 Induced Gen 3: putative quinone oxidoreductase)

Ref: [428-430]

TED2 and related (quinone oxidoreductase involved in Tracheary Element Differentiation in plants)

Ref: [431-435]

^ NRBP1 (nuclear receptor binding protein/transcription factor)


Bifunctional QOR and related

Ref: [439-441]


Ref: [442-448]

^ PER in actinomycetes (probable enoyl reductase in actinomycetes)

Ref: [449;450]

PKS-IAP (polyketide synthase-independent asociated proteins)

Ref: ^ Aspergillus terreus [451-453]; Cochliobolus carbonum [454-457]

QORL-1 (quinone oxidoreductase-like 1)

Ref: [458]

^ DINAP (dinoflagellate nuclear associated protein)

Ref: [459;460]

ARP (auxin regulated protein)

Ref: [461;462]

^ DI-QOR (dark induced-quinone oxidoreductase)

Ref: [463-466]

DI-QOR / ARP related

Unpurified protein; uncharacterized

^ AL (alginate lyase)

Ref: [467-470]

AST (membrane traffic protein)

Ref: [471]

^ BRP (bacteriocin-related proteins)

Ref: Lactococcus lactis [472]; Pediococcus pentosaceus[473]

CCAR (crotonyl-CoA reductase) and related

Ref: Streptomyces (Firmicutes) [474-478]; Pseudomonas (Proteobacteria:  subdivision) [479;480]; Methylobacterium (Proteobacteria:  subdivision) [481;482]

References are listed at the end of suplementary material.

Table S2e. Main subfamilies that conform LTD family (COG2130) of MDR.


LTD (Leucotriene B4 12-hydroxydehydrogenase)/PGR (15-Oxoprostaglandin 13-reductase)

Ref: [483-490]

^ AADH (allyl alcohol dehydrogenase)

Ref: [440;491;492]

LTD/AADH related

Uncharacterized proteins

References are listed at the end of suplementary material.

Table S2f. Main subfamilies that conform ER family (COG3321) of MDR.


^ Enoyl reductase (Fatty acid synthase -FAS-)

Ref: [493-505]

Enoyl reductase (modular polyketide synthase -PKS-)

Ref: [479;493;506-524]

^ Enoyl reductase (iterative polyketide synthase -PKS-)

Ref: [452;453;525;526]

ER -FAS: alveolata (enoyl reductase from type I fatty acid synthase in alveolata)

Ref: [527]

References are listed at the end of suplementary material.

^ Additional References

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