Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, Rm. 406 Bldg. 30, Washington, dc 20375, Ph. 202-404-6051, Fax 202-767-9594 icon

Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, Rm. 406 Bldg. 30, Washington, dc 20375, Ph. 202-404-6051, Fax 202-767-9594


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André A. Adams PhD

U.S. Citizen

Business: Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, Rm. 406 Bldg. 30, Washington, DC 20375, Ph. 202-404-6051, Fax 202-767-9594

Home: 5607 Stillwater Ct., Burke VA 22015, Ph: 571-529-6293 Cell: 225-938-7528

Email: aadadams@gmail.com or andre.adams.ctr@nrl.navy.mil

Executive Summary

Established analytical scientist with extensive biosensor engineering/manufacturing experience.  Expertise encompasses the development of micro/nanofluidic immunoassay platforms directed towards analytes ranging from trace explosives to low abundant biological targets. Research experience obtained in industrial, academic and government settings, providing a unique scientific perspective. A high-performing individual contributor, team player, and technical resource with proven multidisciplinary experience spanning optics, separations, method development, instrument development, as well as analytical characterization. Thrives in collaborative environments within diverse, interdisciplinary teams to achieve shared goals. Excellent written and oral communicator with a meticulous approach, capable of concurrently managing multiple projects.


Education

Ph.D., Biological Analytical Chemistry (06/2008); Novel Devices and Protocols Enabling Isolation and Enumeration of Low Abundant Biological Cells from Complex Matrices; Louisiana State University, Baton Rouge, La., (GPA 4.00/4.00) Adviser: Professor Steven A. Soper

B.S., Chemistry with Honors (05/2000); Grambling State University, Grambling, La., (GPA 3.25/4.00) Adviser: Professor Connie Walton


Research Experience

2008-Present NRC Postdoctoral Research Associate: Advisor: Anne Kusterbeck Ph.D., Naval Research Laboratory, Washington D.C.

  • Designing, fabricating, and implementing novel high throughput microfluidics for displacement immunoassays for environmental contaminants

  • Design, fabrication, and assembly of thermal gradient capillary electrophoresis systems to preconcentrate analytes from dilute samples

  • Developing micromilled and lithographic microfluidic platforms for chemical and microbial analysis

2001-2008 Research Assistant: Advisor: Prof. Steven A. Soper Ph.D., LSU Chemistry, Baton Rouge, La.

  • Designed, fabricated, and assembled polymer-based microfluidic devices for bioassays

  • Developed electrophoretic and hydrodynamic biological cell manipulations in polymer-based microfluidic devices

  • Developed on-chip clinical diagnostics and prognostics using polymer-based BioMEMS

2000-2001 Analytical Chemist: Supervisor: Susan B. Butts Ph.D., DOW Chemical Company,

Plaquemine, La.

  • QC/QA using XRF, ICP, IC, and AAS in support of production plants

  • Wet and dry ashing of polymer samples

  • Automated titrations and chemical extractions

1999 Research Assistant: Advisor: William T. Stringfellow, Lawrence Berkeley National Laboratory, Berkeley, Ca.

  • Developed SPME/GC/MSn methods for the analysis VOCs and their metabolites

  • Compiled reports and analyzed data to determine efficacy of biodegradation

  • Facilitated biodegradation of MTBE contaminated water in pilot scale bioreactors

1998-2000 Research Assistant/Teaching Assistant: Advisor: Prof. Danny Hubbard, Grambling State University, Grambling, La.

  • Analyzed water samples for lead using AAS

  • Molecular modeling of inorganic complexes

  • Managed chemistry department computer lab

Skills and Techniques

  • Micro/nano fabrication, design, manufacture, and validation of metal mould inserts and polymeric microdevices via UV and x-ray LIGA as well as direct and indirect micromilling

  • Microchip capillary electrophoresis as well as on-chip single cell (CTC) manipulations to isolate low abundant adenocarcinoma related cellular events from biological fluids

  • Culture and maintenance of adenocarcinoma related cell lines as well as tumor specific antigens that serve as biomarkers

  • Conjugation of proteins, nucleic acids, and polymeric surfaces using carbodiimide and succinimidyl ester based chemistries

  • Thoroughly experienced in analytical techniques and methods development involving bright-field and fluorescence microscopy, SEM, UV-Visible spectroscopy, fluorescence spectroscopy, Thermal Gradient Focusing, AAS, FT-IR, SPME/GC/MSn, ICP, IC, HPLC, and CE


^ Selected Patents and Publications

  1. Udara Dharmasiri, Małgorzata A. Witek, Andre A. Adams, John K. Osiri, Mateusz L. Hupert, Thomas S. Bianchi,| Daniel L. Roelke, and Steven A. Soper, 2010 “Enrichment and Detection of Escherichia coli O157:H7 from Water Samples Using an Antibody Modified Microfluidic Chip”, Analytical Chemistry, 82(7), 2844-2849.

  2. Udara Dharmasiri, Malgorzata A. Witek, André A. Adams, and Steven A. Soper, 2010, “Microsystems for the Capture of Low Abundance Cells”, Annual Review of Analytical Chemistry, 3 (1).

  3. Paul T. Charles, Andre A. Adams, Peter B. Howell, Jr., Scott A. Trammell, Jeffrey R. Deschamps and Anne W. Kusterbeck, 2010, Fluorescence-based Sensing of 2,4,6-Trinitrotoluene (TNT) Using a Multi-channeled Poly(methyl methacrylate) (PMMA) Microimmunosensor, Sensors, 10(1), 876-889.

  4. Udara Dharmasiri, Subramanian Balamurugan, André A. Adams, Paul I. Okagbare, and Steven A. Soper, 2009, “Highly Efficient Capture and Enumeration of Low Abundance Prostate Cancer Cells Using Prostate-Specific Membrane Antigen Aptamers Immobilized to a Polymeric Microfluidic Device”, Electrophoresis, 30(18), 3289-3300.

  5. André A. Adams, Juan Feng, Robin L. McCarley, Michael C. Murphy, and Steven A. Soper, 2008, “New Microdevice for Capturing or Isolating Selected Cells from a Liquid and for Isolating and Enumerating Rare Cells, Comprises Parallel Channels that are Fluidically Connected to a Common Input and to a Common Output”, U.S. Patent and Trade Office, WO2009140326-A2; WO2009140326-A3.

  6. André A. Adams, Mateusz Hupert, Paul I. Okagbare, Michael C. Murphy, Robin L. McCarley, and Steven A. Soper, 2008, “Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor”, Journal of the American Chemical Society, 130(27), 8633-8641.

  7. André A. Adams, Suying Wei, Juan Feng, Robin L. McCarley, Michael C. Murphy, David Spivak and Steven A. Soper, 2004, “Low Abundant Biomarker Screening in Poly(methylmethacrylate) High Aspect Ratio Microstructures Using Immunoaffinity-Based Molecular Recognition”, Special Publication: Royal Society of Chemistry – Miniaturized Total Analysis Systems, 1(296), 132-134.

  8. Malgorzata A. Witek, Suying Wei, Bikas Vaidya, André A. Adams, Li Zhu, Wieslaw Stryjewski, Robin L. McCarley and Steven A. Soper, 2004, “Cell transport via electromigration in polymer-based microfluidic devices”, Lab on a Chip, 4(5), 464-472.


Selected Presentations and Invited Lectures

  • High-Throughput Analysis of Nitroaromatic Compounds via Displacement Based Immunoassays, NRL CBMSE Seminar Series, Washington DC., 2010.

  • High Aspect Ratio Microfluidic Systems for Quantitation of Nitroaromatics, Pittsburg Conference, Orlando Fl., 2010.

  • Novel Devices and Protocols Enabling isolation and Enumeration of Low Abundant Biological Cells from Complex Matrices, Oak Ridge National Laboratory, Oak Ridge Tn., 2008.

  • Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor, Naval Research Laboratory, Washington D.C., 2008.

  • Circulating Tumor Cell Isolation and Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor, Center for Bio-Modular Multi-scale Systems, Baton Rouge La., 2007.

  • Circulating Tumor Cell Capture from Peripheral Blood Using PMMA Microdevices, 17th Annual NSF/EPSCoR National Conference, Lexington, Ky., 2006.

  • Isolation and Enumeration of Circulating Tumor Cells Using Antibody Immobilized Polymer-Based High Throughput Microsampling Units, LSU Chemistry Departmental Research Seminar, Baton Rouge, La., 2006.

  • Isolation and Enumeration of Circulating Tumor Cells from Peripheral Blood Using Antibody Immobilized Polymer-Based High Throughput Microsampling Units, CBM2 Colloquium Baton Rouge, La., 2006.

  • Low Abundant Biomarker Screening In Poly (Methylmethacrylate) High Aspect Ratio Microstructures Using Immunoaffinity-Based Molecular Recognition, Micro Total Analysis Systems Conference, Malmo, Sweden, 2004.

  • Cell Transport in Pristine and UV Modified Polymer Based Microfluidic Devices: A Precursor for Low Abundant Biomarker Screening, 31st Annual National Organization of Black Chemists and Chemical Engineers Conference, San Diego, Ca., 2004.

  • MTBE Analysis in Water Employing SPME-GC/MS, 4th Annual DOE/EPSCoR HRD and LS-Lamp Research Conference, Baton Rouge, La., 2000.

  • Determinations of MTBE in H2O with SPME-GC/MS, 27th Annual National Organization of Black Chemists and Chemical Engineers Conference, Miami, Fl., 2000.

  • SPME-GC/MS Determinations of MTBE in Bioremediated Water, Department of Energy/Energy Research Undergraduate Laboratory Fellowship Symposium, Berkeley, Ca., 1999.

  • MTBE Analysis in Water Using SPME-GC/MS, 26th Annual National Organization of Black Chemists and Chemical Engineers Conference, San Diego, Ca., 1999.

  • MTBE Analysis in Water Using SPME-GC/MS, 3rd Annual DOE EPSCoR HRD and LS-Lamp Research Conference, Baton Rouge, La., 1999.


Service and Leadership

    1. Gordon Research Conferences Graduate Research Seminar on Biosensors

  • Served as conference chair in 2008 and served as vice-Chair in 2006

  • Procured funds to support meeting attendance by an international group of biosensors researchers

  • Reviewed abstracts that were submitted selected presenters and determined oral or poster assignments

  • Arranged the conference program and coordinated the event with GRC and biosensors conference

2003-2004 Louisiana State University Chemistry Graduate Student Council, President

  • Delegated administrative responsibilities to subordinates

  • Served as the liaison between faculty and graduate assistants

  • Organized fundraising efforts

2002-2003 National Organization for the Professional Advancement of Chemists and Chemical Engineers Student Affiliate Chapter, President

  • Streamlined fundraising efforts by developing a notes sales effort

  • Implemented program of community outreach that put young scientists in classrooms

  • Delegated administrative responsibility to subordinates


Teaching and Mentoring Experience

Teaching Assistant, Louisiana State University, Department of Chemistry

  • Instrumental Characterization of Organic Compounds (Senior Level - 4 sem.)

    • Developed methods for experiments employing both separations and spectroscopic techniques

    • Mentored students and guided the independent research in the pursuit of projects

    • Coordinated other TAs and instrumentation

  • Quantitative Analysis (Sophomore Level - 1 sem.)

  • General Chemistry (Freshmen Level - 1 sem.)

  • Mentored new graduate students within the Soper Research Group

  • Trained new students on instrumentation and preferred scientific software

  • Setup and maintained instrumentation computers as well as the common computer lab


Selected Awards

  • National Research Council Research Associateship Program Award, 2008

  • Excellence in Teaching Analytical Chemistry Award Recipient, 2008

  • P&G Research and Technical Careers in Industry Conference Award Recipient, 2007

  • 1st Place Research Seminar Award, Louisiana State University, Department of Chemistry, 2007

  • 2nd Place Poster Presentation Award, Center for Bio-Modular Multi-Scale Systems Poster Competition, 2006

  • 1st Place Poster Presentation Award, 8th Annual Miniaturized Total Analysis Systems Conference, Malmo, Sweden, 2004

  • 1st Place in oral presentation competition at the 4th Annual DOE EPSCoR HRD and LS-Lamp Research Conference, 2000

  • Annual Richard Rayford Outstanding Chemistry Major Award recipient, 1999, 2000

  • Department of Energy/Energy Research Undergraduate Laboratory Fellowship recipient, 1999

  • United States Achievement Academy, All-American Scholar, Fall 1999


Affiliations

  • Gordon Research Conference’s, Gordon-Kenan Seminars on Bioanalytical Sensors, Chair 2008, Vice Chair 2006.

  • American Academy for the Advancement of Science, 2001-Present

  • American Chemical Society, 1998-Present

  • LSU Chemistry Graduate Student Council, President, 2003-2004

  • National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (Student Affiliate Chapter, President, 1999-2000 (GSU), 2002-2003(LSU)), 1996-Present

  • Alpha Phi Alpha Fraternity, Inc. (Social Organization)

  • Beta Kappa Chi (Scientific Honor Society)

  • Pi Mu Epsilon (Mathematics Honor Society)

  • Golden Key (National Honor Society)



References


Anne W. Kusterbeck Ph.D.

Research Advisor

Center for Bio/Molecular Science and Engineering, CBMSE

Naval Research Laboratory

4555 Overlook Ave. SW

Rm. 223A Bldg. 30

Washington D.C. 20375

Wk. 202-404-6042

anne.kusterbeck@nrl.navy.mil


Prof. Steven A. Soper Ph.D.

Research Advisor

Director of the Center for Bio-Modular Multi-Scale Systems, CBM2

Louisiana State University

Department of Chemistry

307 Choppin Hall

Baton Rouge, LA 70803

Wk. 225-578-1527

chsope@lsu.edu


Susan B. Butts, Ph.D.
Sr. Director of the External Science & Technology Programs

The Dow Chemical Company
1776 Eye Street
Suite 1050
Washington, DC 20006
Wk: 202-429-3438
sbbutts@dow.com


William T. Stringfellow Ph.D.

Director of the Environmental Measurements Laboratory

Lawrence Berkeley National Laboratory

1 Cyclotron Road
MS:70A-3317
Berkeley, CA 94720
Wk: 510-486-7903
wstringfellow@lbl.gov


Prof. Connie Walton Ph.D.

Dean of the College of Arts and Sciences

Grambling State University

Carver Hall 114

Grambling, LA 71245

Wk. 318 274-4006

waltoncr@gram.edu


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